117525-25-4Relevant articles and documents
A new method for synthesis and angiogenic evaluation of leteprinim potassium and its novel analogs
Sakakibara, Norikazu,Tsukamoto, Ikuko,Isono, Yohei,Takata, Maki,Konishi, Ryoji,Kato, Yoshihisa,Maruyama, Tokumi
, p. 2369 - 2384 (2013)
We developed a novel pathway for the successful synthesis of leteprinim potassium 1, which is one of the candidate substances for treating Alzheimer's disease, and subsequently synthesized 4 types of corresponding novel derivatives 2-5 that have hypoxanthine or 2-chloro-6-aminopurine as the nucleobase. We then determined the angiogenic activity of these compounds by using human umbilical vein endothelial cells. Compounds 1-4 showed no angiogenic potencies judging from statistical analysis, student's t-test.
Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-amino prodrugs of 2′-β-fluoro-2′,3′-dideoxyinosine
Driscoll, John S.,Siddiqui, Maqbool A.,Ford Jr., Harry,Kelley, James A.,Roth, Jeri S.,Mitsuya, Hiroaki,Tanaka, Masatoshi,Marquez, Victor E.
, p. 1619 - 1625 (2007/10/03)
A series of 6-substituted amino analogs of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl) purines (F-ddN) has been synthesized and characterized with the objective of finding compounds which might be superior to existing drugs for the treatment of HIV
Enhanced Brain Delivery of an Anti-HIV Nucleoside 2'-F-ara-ddI by Xanthine Oxidase Mediated Biotransformation
Shanmuganathan, Kirupa,Koudriakova, Tatiana,Nampalli, Satyanarayana,Du, Jinfa,Gallo, James M.,et al.
, p. 821 - 827 (2007/10/02)
In order to enhance the brain delivery of 2'-F-ara-ddI, 2'-F-ara-ddP 6 was synthesized and its in vitro and in vivo bioconversion reaction studied.For the study, a new efficient synthetic method for 2'-F-ara-ddP 6 was developed from 5-benzoyl-1,2-O-isopro
