117527-59-0Relevant articles and documents
Synthesis, isolation, and characterization of 2′-paclitaxel glycinate: An application of the Bsmoc protecting group
Greenwald, Richard B.,Zhao, Hong,Reddy, Prasanna
, p. 4894 - 4896 (2003)
The relevance of the Bsmoc protecting group in the synthesis of moisture- and base-sensitive compounds has been demonstrated by the preparation of 2′-paclitaxel glycinate with use of the solid anhydrous base, 4-piperidinopiperidine in DCM solvent.
DUAL PHASE DRUG RELEASE SYSTEM
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Page/Page column 83, (2008/06/13)
The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a modifier having a molecular weight ≤ 10 kDa; denotes direct of indirect attachment of M to linker LM; and each occurrence of LM is independently an optionally substituted succinamide-containing linker, whereby the modifier M is directly or indirectly attached to the succinamide linker through an amide bond, and the carrier is linked directly or indirectly to each occurrence of the succinamide linker through an ester bond. In another aspect, the invention provides compositions comprising the conjugates, methods for their preparation, and methods of use thereof in the treatment of various disorder, including, but not limited to cancer.
Paclitaxel delivery systems: The use of amino acid linkers in the conjugation of paclitaxel with carboxymethyldextran to create prodrugs
Sugahara, Shu-Ichi,Kajiki, Masahiro,Kuriyama, Hiroshi,Kobayashi, To-Ru
, p. 632 - 641 (2007/10/03)
Paclitaxel was bound via its hydroxyl group to carboxymethyldextran (CMDex, 150 kDa) by means of an amino acid linker; the linker was introduced into the 2′- or 7-hydroxyl group of the paclitaxel through an ester bond. These conjugates - CMDex-2′-paclitax
