1175513-07-1Relevant articles and documents
Identification of small molecule agonists of the motilin receptor
Heightman, Tom D.,Conway, Elizabeth,Corbett, David F.,Macdonald, Gregor J.,Stemp, Geoffrey,Westaway, Susan M.,Celestini, Paolo,Gagliardi, Stefania,Riccaboni, Mauro,Ronzoni, Silvano,Vaidya, Kalindi,Butler, Sharon,McKay, Fiona,Muir, Alison,Powney, Ben,Winborn, Kim,Wise, Alan,Jarvie, Emma M.,Sanger, Gareth J.
scheme or table, p. 6423 - 6428 (2009/10/01)
High-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure-activity relationship within the series resulted in the identification of compound (22) as a potent and selective agonist at the motilin receptor.
