1175526-55-2

Basic information

• Product Name: (2'-{[(3-chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid
• CAS NO: 1175526-55-2
• Molecular Weight: 535.947
• Mol File: 1175526-55-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2'-{[(3-chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2'-{[(3-chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid(1175526-55-2)
• EPA Substance Registry System: (2'-{[(3-chloro-benzyloxycarbonyl)-ethyl-amino]-methyl}-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid(1175526-55-2)

Safety Data

• Hazardous Substances Data: 1175526-55-2(Hazardous Substances Data)

Upstream product

• 100125-96-0 (3-bromo-4-methoxy-phenyl)-acetic acid ethyl ester 
• 774-81-2 (3-bromo-4-methoxy-phenyl)-acetic acid 
• 873-63-2 m-chlorobenzyl alcohol 
• 1175526-04-1 (2'-ethylaminomethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester 
• 39545-30-7 m-chlorobenzyl chloroformate 
• 1175526-30-3 (2'-formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester 
• 1347747-25-4 C₂₉H₂₉ClF₃NO₅ 
• 1175525-91-3 [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester 

Relevant articles and documents

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

Biphenylacetic acid (5) was identified through a library screen as an inhibitor of the prostaglandin D2 receptor DP2 (CRTH2). Optimization for potency and pharmacokinetic properties led to a series of selective CRTH2 antagonists. Compounds demonstrated potency in a human DP2 binding assay and a human whole blood eosinophil shape change assay, as well as good oral bioavailability in rat and dog, and efficacy in a mouse model of allergic rhinitis following oral dosing.