1175563-13-9Relevant academic research and scientific papers
Structural insights into a unique inhibitor binding pocket in kinesin spindle protein
Ulaganathan, Venkatasubramanian,Talapatra, Sandeep K.,Rath, Oliver,Pannifer, Andrew,Hackney, David D.,Kozielski, Frank
, p. 2263 - 2272 (2013/03/28)
Human kinesin Eg5 is a target for drug development in cancer chemotherapy with compounds in phase II clinical trials. These agents bind to a well-characterized allosteric pocket involving the loop L5 region, a structural element in kinesin-5 family member
Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors
Lahue, Brian R.,Ma, Yao,Shipps Jr., Gerald W.,Seghezzi, Wolfgang,Herbst, Ronald
scheme or table, p. 3405 - 3409 (2010/02/28)
Substituted benzimidazoles were profiled as inhibitors of kinesin spindle protein (KSP), an increasingly important target for the development of anticancer drugs. This series demonstrated the monoastral phenotypic response and was found to be active in bo
