117568-53-3Relevant articles and documents
Role of hydroxyl groups on the aromatic ring in the reactivity and selectivity of the reaction of β -phenylethylamines with non-enolizable aldehydes
Quevedo, Rodolfo,Díaz-Oviedo, Christian,Quevedo-Acosta, Yovanny
, p. 9835 - 9843 (2015)
The influence of hydroxyl groups on the β-phenylethylamine aromatic ring was studied during its reaction with non-enolizable aldehydes. Computational calculations established that the degree of hydroxylation generates differences in the activation pattern
The Synthesis of 2-Arylmethyltetrahydroisoquinolines from Bis(Aminol) Ethers Involving Two Iminium Salt Intermediates
Heaney, Harry,Papageorgiou, George,Wilkins, Robert F.
, p. 10737 - 10750 (2007/10/02)
The bis(aminol) ether derived from 3,4-dimethoxy-β-phenylethylamine, methanol, and formaldehyde reacts with trichloromethylsilane to afford an equilibrium mixture of N-chloromethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and its related iminium chloride.Interaction with electron rich aromatic compounds afford good yields of N-arylmethyl derivatives, including sendaverine methyl ether.Reactions of the bis(amino) ether in the presence of the aromatic substrate allows the formation of the N-arylmethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in a one pot reaction.