117621-64-4 Usage
Uses
ICI 192,605 is a potent thromboxane A2 receptor antagonist.
Biological Activity
Potent thromboxane A 2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U46619 .
Check Digit Verification of cas no
The CAS Registry Mumber 117621-64-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,6,2 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 117621-64:
(8*1)+(7*1)+(6*7)+(5*6)+(4*2)+(3*1)+(2*6)+(1*4)=114
114 % 10 = 4
So 117621-64-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H23ClO5/c23-18-11-6-4-9-16(18)22-27-14-15(8-2-1-3-13-20(25)26)21(28-22)17-10-5-7-12-19(17)24/h1-2,4-7,9-12,15,21-22,24H,3,8,13-14H2,(H,25,26)/b2-1-/t15-,21+,22+/m1/s1
117621-64-4Relevant articles and documents
PPAR Modulators
-
, (2011/08/04)
1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and infections.
Improved synthetic routes to the novel thromboxane receptor antagonist ICI 192605: Activity of synthetic 1.3-dioxane intermediates
Brown,Foubister,Hudson
, p. 53 - 55 (2007/10/02)
A study of the synthetic routes to the thromboxane receptor antagonist ICI 192605 4(Z)-6-(2-o-chlorophenyl-4- o-hydroxyphenyl- 1,3-dioxan-cis-5-yl) hexenoic acid is described which led to an improvement in overall synthetic yield from 20 to 55%. In-vitro