117638-50-3Relevant academic research and scientific papers
Process for the selective N-formylation of N-hydroxylamines
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, (2008/06/13)
The instant invention provides a process for the selective N-formylation of N-hydroxylamines.
Enzymatic synthesis of optically active hydroxamic acids and their conversion to optically active primary amines by a lossen rearrangement
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, (2008/06/13)
A method is described for the preparation of optically active hydroxamic acids of the general formula wherein R1, R2and R3are different and are a cyclic or linear, aliphatic or aromatic, substituted or unsubstituted hydrocarbon radical which can optionally contain heteroatoms, said method being characterized in that a racemate of chiral amides, carboxylic acid esters or carboxylic acids of the general formula wherein R1, R2and R3are as defined above and X is —NH2, —OR or —OH, R being any organic radical, is reacted with hydroxylamine, NH2OH, in the presence of an acyltransferase, and the optically active hydroxamic acid (I) formed is then separated from the unconverted enantiomer of general formula (II). The resulting optically active hydroxamic acid can be converted to the corresponding optically active primary amines by a Lossen rearrangement.
KINETIC RESOLUTION OF ACIDS IN ACYLATION REACTIONS IN THE PRESENCE OF CHIRAL TERTIARY AMINES
Potapov, V. M.,Dem'yanovich, V. M.,Khlebnikov, V. A.
, p. 301 - 305 (2007/10/02)
During the acylation of alcohols and amines by the action of racemic 2-phenylpropionic and 2-methyl-3-phenylpropionic acids in the presence of S-nicotine the initial acids are resolved kinetically.The (R)-2-phenylpropionic acid obtained in this way had an optical purity of 0.5-1.5percent.
