1176472-40-4

Upstream product

• 583-68-6 2-bromo-p-toluidine 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 

Downstream Products

• 1426812-90-9 N-(2-(benzo[d][1,3]dioxol-5-yl)-4-methylphenyl)-4-methylbenzenesulfonamide 
• 1426813-13-9 2-methyl-5-tosyl-[1,3]dioxolo[4,5-j]phenanthridin-6(5H)-one 

Relevant academic research and scientific papers

Photoredox-Catalyzed Tandem Insertion/Cyclization Reactions of Difluoromethyl and 1,1-Difluoroalkyl Radicals with Biphenyl Isocyanides

Using visible-light photoredox conditions, difluoromethylation and 1,1-difluoroalkylation of biphenyl isocyanides have allowed the synthesis of a series of 6-(difluoromethyl)- and 6-(1,1-difluoroalkyl)phenanthridines via tandem addition/cyclization/oxidation processes. The reactions are carried out in wet dioxane at room temperature using fac-Ir(ppy)3 as catalyst to form a large variety of substituted phenanthridine products in good to excellent yield.

6-Trifluoromethyl-phenanthridines through radical trifluoromethylation of isonitriles

A radical approach toward 6-perfluoroalkylphenanthridines employs the Togni reagent or derivatives thereof as radical precursors and occurs in the absence of a transition metal. Bu4NI is applied as radical initiator and phenanthridines are formed in good to excellent yields. In contrast to the currently intensively investigated trifluoromethylation of arenes, the arene core is formed during the trifluoromethylation in this approach. Copyright

Electrochemical initiation of electron-catalyzed phenanthridine synthesis by trifluoromethylation of isonitriles

The electron-catalyzed formation of phenanthridines starting from isonitriles initiated by an electrochemical reduction of the Togni reagent is presented. The required number of faradays per mole of starting material and the respective yields clearly show the catalytic character of the electron in this reaction. The mechanism is supported by cyclic voltammetry experiments.

Palladium-catalyzed oxidative insertion of carbon monoxide to N -sulfonyl-2-aminobiaryls through C-H bond activation: Access to bioactive phenanthridinone derivatives in one pot

Palladium-catalyzed oxidative carbonylation of N-sulfonyl-2-aminobiaryls through C-H bond activation and C-C, C-N bond formation under TFA-free and milder conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important phenanthridinone derivatives in yields up to 94%.