117653-35-7

Basic information

• Product Name: 2-methyl-1-(phenylmethyl) 4-<2-(1,1-dimethylethoxy)-2-oxoethylidene>-1,2-pyrrolidinedicarboxylate
• CAS NO: 117653-35-7
• Molecular Weight: 375.422
• Mol File: 117653-35-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methyl-1-(phenylmethyl) 4-<2-(1,1-dimethylethoxy)-2-oxoethylidene>-1,2-pyrrolidinedicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1-(phenylmethyl) 4-<2-(1,1-dimethylethoxy)-2-oxoethylidene>-1,2-pyrrolidinedicarboxylate(117653-35-7)
• EPA Substance Registry System: 2-methyl-1-(phenylmethyl) 4-<2-(1,1-dimethylethoxy)-2-oxoethylidene>-1,2-pyrrolidinedicarboxylate(117653-35-7)

Safety Data

• Hazardous Substances Data: 117653-35-7(Hazardous Substances Data)

Upstream product

• 41108-81-0 tert-butyl (trimethylsilyl)acetate 
• 16217-15-5 1-benzyloxycarbonyl-4-oxo-L-proline methyl ester 

Downstream Products

• 168034-47-7 (2S,4R)-4-tert-Butoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 147235-94-7 (2S,4R)-4-(carboxymethyl)pyrrolidine-2-carboxylic acid 
• 147235-94-7 (2S,4S)-4-(carboxymethyl)pyrrolidine-2-carboxylic acid 
• 168112-50-3 methyl (2S,4R)-4-<(menthyloxycarbonyl)methyl>pyrrolidine-2-carboxylate 
• 168034-52-4 methyl (2S,4S)-4-<(menthyloxycarbonyl)methyl>pyrrolidine-2-carboxylate 

Relevant articles and documents

Synthesis of all four diastereoisomers of 4-(carboxymethyl)proline, a conformationally constrained analogue of 2-aminoadipic acid

The dirhodium(II) tetraacetate catalysed reaction of ethyl diazoacetate with 2,3-dihydropyrrole-2,2-dicarboxylate 5 afforded the useful 2-azabicyclohexane 6.Its conversion into the proline-γ-acetic acid equivalent 9 as well as into the four isomers constituting the 4-(carboxymethyl)proline 13 (16a-19a) whose absolute configuration was established by an alternative asymmetric synthesis of two of them is described.Preliminary data concerning the affinity of compounds 16a-19a for the NMDA site of the NMDA receptor complex are also reported.