117664-56-9

Upstream product

• 331-98-6 N-benzylidene-4-fluoroaniline 
• 68-11-1 mercaptoacetic acid 

Downstream Products

• 117664-60-5 5-Bromo-3-(4-fluoro-phenyl)-2-phenyl-thiazolidin-4-one 
• 117664-74-1 4-(4-Fluoro-phenyl)-3,5-diphenyl-4,5-dihydro-3H-thiazolo[4,5-d]thiazole-2-thione 
• 117664-71-8 [6-(4-Fluoro-phenyl)-5-phenyl-5,6-dihydro-1-oxa-3,4-dithia-6-aza-pentalen-(2E)-ylidene]-phenyl-amine 
• 117664-67-2 [6-(4-Fluoro-phenyl)-5-phenyl-5,6-dihydro-[1,3]dithiolo[4,5-d]thiazol-(2E)-ylidene]-phenyl-amine 
• 117664-63-8 Phenyl-dithiocarbamic acid 3-(4-fluoro-phenyl)-4-oxo-2-phenyl-thiazolidin-5-yl ester 

Relevant academic research and scientific papers

A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO4·5H2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid

Mesoporous MCM-41 supported Schiff base and CuSO4·5H2O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving two-components or three-components afforded the desired product in high yields (up to 98% and 99%). Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.

Intramolecular Chemoselective Heterocyclisation of Oxothiazolidin-5yl N-Aryldithiocarbamates to Fungitoxic 1,3-Dithiolo-1,3-Oxathiolo- and Thiazolo-thiazoles

Substituted 1,3-dithiolothiazoles (IVa-d), 1,3-oxathiolothiazoles (Va-d) and thiazolothiazoles (VIa-d) have been synthesised by the intramolecular chemoselective heterocyclisation of 4-oxathiazolidin-5-yl N-aryldithiocarbamates (IIIa-d) with conc.H2SO4, CH3I and NaOH, respectively.The compounds III-VI were compared with Dithiane M-45 for their fungitoxicity against A. niger and F. oxysporium.Based on screening data, a possible structure-activity relationship has been deduced.