117671-78-0

Basic information

• Product Name: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-5,5-bis-methylsulfanyl-penta-2,4-dien-1-one
• Synonyms: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-5,5-bis-methylsulfanyl-penta-2,4-dien-1-one
• CAS NO: 117671-78-0
• Molecular Weight: 300.83
• Mol File: 117671-78-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-5,5-bis-methylsulfanyl-penta-2,4-dien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-5,5-bis-methylsulfanyl-penta-2,4-dien-1-one(117671-78-0)
• EPA Substance Registry System: (Z)-1-(4-Chloro-phenyl)-3-hydroxy-5,5-bis-methylsulfanyl-penta-2,4-dien-1-one(117671-78-0)

Safety Data

• Hazardous Substances Data: 117671-78-0(Hazardous Substances Data)

Upstream product

• 1126-46-1 Methyl 4-chlorobenzoate 
• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 

Downstream Products

• 117671-83-7 2-(4-Chloro-phenyl)-6-methylsulfanyl-pyran-4-one 

Relevant articles and documents

Polarized Ketene Dithioacetals; 53: A Facile Synthesis of 2-Aryl-6-methylthio-4H-pyran-4-ones and a Novel Cycloaromatization Reaction

A facile route to hitherto unreported 2-aryl-6-methylthio-4H-pyran-4-ones 4a-f has been developed by base-catalyzed condensation of acylketene dithioacetal 2 with substituted methyl benzoates 1a-f followed by subsequent ring closure of resulting α-aroylacylketene dithioacetals 3a-f.Acylketene dithioacetal 2 and the corresponding β-methylthioenone 9 are shown to undergo self-condensation and aromatization in the presence of sodium hydride and methylbenzoate in refluxing xylene to give 2,6-bis(methylthio)-4-hydroxy-acetophenone (6) and 4-hydroxyacetophenone (10) respectively in good yields.A mechanistic pathway for the formation of 6 and 10 via 3 has been described.