117672-14-7

Upstream product

• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 117953-54-5 (2Z,4E)-5-(3,4-Dimethoxy-phenyl)-3-hydroxy-penta-2,4-dienoic acid methyl ester 
• 132610-18-5 1-<2-bis(methylthio)methyleneacetyl>-2-(3,4-dimethoxyphenyl)cyclopropane 
• 132916-79-1 2-Acetoxy-5,5-bis(methylthio)-4-(3,4-dimethoxyphenyl)-2-cyclopenten-1-one 
• 137612-75-0 3-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-5-methylsulfanyl-1H-pyrazole 
• 117671-95-1 1-[(2S,3R)-3-(3,4-Dimethoxy-phenyl)-oxiranyl]-3,3-bis-methylsulfanyl-propenone 
• 128951-15-5 4-[(E)-2-(3,4-Dimethoxy-phenyl)-vinyl]-2-hydroxy-6-methylsulfanyl-benzoic acid ethyl ester 
• 128032-00-8 ethyl 3-(3,4-dimethoxystyryl)-5-methylthio furan-2-carboxylate 
• 128032-05-3 ethyl 3-<2-carbethoxy-3-(3,4-dimethoxyphenyl)cycloprop-1-yl>-5-methylthio furan-2-carboxylate 
• 117672-11-4 5-(3,4-Dimethoxy-phenyl)-2-methylsulfanyl-pyran-4-one 
• 117672-03-4 (Z)-2-(3,4-Dimethoxy-phenyl)-3-hydroxy-5,5-bis-methylsulfanyl-penta-2,4-dienal 
• 117926-33-7 3-(3,4-dimethoxyphenyl)cyclopentanone 
• 132610-47-0 (E)-methyl 5-(3,4-dimethoxyphenyl)-2-oxocyclopentanecarboxylate 
• 132610-34-5 (E)-S-methyl 5-(3,4-dimethoxyphenyl)-2-oxocyclopentanecarbothioate 
• 132610-44-7 2-bis(methylthio)methylene-3-(3,4-dimethoxyphenyl)cyclopentanone 

Relevant academic research and scientific papers

Chemotherapy of leishmaniasis part II: Synthesis and bioevaluation of substituted arylketene dithioacetals as antileishmanial agents

Some novel aryl substituted ketene dithioacetals 6 (a-d), 9 (a-c) and 10 (a-c) have been synthesized using novel synthetic methods. The compounds were screened against Leishmania donovani in hamsters for their activity profile. Some of the compounds inhibited 50-65% parasite growth at 50mg kg-1 × 5 days.

Convenient one-pot multicomponent strategy for the synthesis of 6-pyrrolylpyrimidines

We have developed an easy method to construct diheteroaryls from α-aroylidineketene dithioacetals in a multicomponent manner. The reaction proceeded with high chemo/regioselectivity to yield 4-alkoxy-6-(4-aryl-1H- pyrrol-3-yl)pyrimidin-2-amines under mild