1176777-79-9Relevant academic research and scientific papers
Exploring tertiary enamides as versatile synthons in organic synthesis
Wang, Mei-Xiang
, p. 6039 - 6049 (2015/04/14)
Tertiary enamides have long been thought of as stable and marginally valuable enamine variants in synthesis. This notion has been challenged, however, in recent years. Enabling the regulation of the cross-conjugation system of the tertiary enamides has been successfully shown to enhance delocalization of the nitrogen lone-pair electrons into a carbon-carbon double, thereby reinvigorating the enaminic reactivity of the tertiary enamides. In this article, I summarize the recent advances in the exploration of the nucleophilic reactions of tertiary enamides and their applications in the synthesis of natural products and heterocyclic compounds of biological and pharmaceutical relevance, with a primary focus on our own work.
Cr(III)(salen)Cl catalyzed enantioselective intramolecular addition of tertiary enamides to ketones: A general access to enantioenriched 1H-pyrrol-2(3H)-one derivatives bearing a hydroxylated quaternary carbon atom
Yang, Luo,Wang, De-Xian,Huang, Zhi-Tang,Wang, Mei-Xiang
supporting information; experimental part, p. 10390 - 10391 (2009/12/04)
(Chemical Equation Presented) Catalyzed by a chiral Cr(III)(salen)Cl complex 3e, tertiary enamides 1 underwent an efficient and enantioselective intramolecular addition reaction to an activated carbonyl moiety to produce in excellent yield highly enantioe
