1176788-91-2Relevant academic research and scientific papers
Structure-guided development of selective TbcatB inhibitors
Mallari, Jeremy P.,Shelat, Anang A.,Kosinski, Aaron,Caffrey, Conor R.,Connelly, Michele,Zhu, Fangyi,McKerrow, James H.,Kiplin Guy
experimental part, p. 6489 - 6493 (2010/03/31)
The trypanosomal cathepsin TbcatB is essential for parasite survival and is an attractive therapeutic target. Herein we report the structure-guided development of TbcatB inhibitors with specificity relative to rhodesain and human cathepsins B and L. Inhib
