117682-19-6

Upstream product

• 136918-14-4 phthalimide 
• 612-12-4 o-Xylylene dichloride 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 38379-25-8 o-chloromethylbenzylamine 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 945995-54-0 2-(2-{[(6-methyl-2-oxo-1,2-dihydropyridin-4-yl)oxy]methyl}benzyl)-1H-isoindole-1,3(2H)-dione 
• 945996-11-2 methyl 3-[4-({2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzyl}oxy)-2-(methylthio)-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoate 
• 945995-40-4 4-{[2-(aminomethyl)benzyl]oxy}-3-chloro-1-(4-chloro-3-methoxybenzyl)-6-methylpyridin-2(1H)-one 
• 945995-44-8 tert-butyl 3-((4-(2-((1,3-dioxoisoindolin-2-yl)methyl)benzyloxy)-3-chloro-6-methyl-2-oxopyridin-1(2H)-yl)methyl)benzylcarbamate 
• 945995-39-1 2-[2-({[3-chloro-1-(4-chloro-3-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]-1H-isoindole-1,3(2H)-dione 
• 945995-34-6 2-(2-((1-(3-chloro-4-methoxybenzyl)-1,2-dihydro-3-iodo-6-methyl-2-oxopyridin-4-yloxy)methyl)benzyl)isoindoline-1,3-dione 
• 945995-17-5 2-(2-((1-(3-methoxybenzyl)-3-chloro-6-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)benzyl)isoindoline-1,3-dione 
• 945995-19-7 2-(2-((1-(3-methoxybenzyl)-3-iodo-6-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)benzyl)isoindoline-1,3-dione 
• 945993-32-8 2-[2-({[3-chloro-1-(3-chloro-4-methoxybenzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yl]oxy}methyl)benzyl]-1H-isoindole-1,3(2H)-dione 
• 945995-05-1 2-(2-((1-(2-methoxybenzyl)-1,2-dihydro-3-iodo-6-methyl-2-oxopyridin-4-yloxy)methyl)benzyl)isoindoline-1,3-dione 
• 945995-02-8 2-(2-((1-(2-methoxybenzyl)-3-chloro-1,2-dihydro-6-methyl-2-oxopyridin-4-yloxy)methyl)benzyl)isoindoline-1,3-dione 
• 945994-90-1 2-(2-((1-(2-(methylthio)benzyl)-6-methyl-2-oxo-1,2-dihydropyridin-4-yloxy)methyl)benzyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands

New cis-, trans-2-butene and 1,2-bismethylbenzene analogues of MM77 and NAN-190 (1-{4-[4-(2-methoxyphenyl)-piperazin-1-yl]-butyl}-pyrrolidine-2,5-dione and isoindole-1,3-dione, respectively) were synthesized. The differences in their in vitro affinity for serotonin 5-HT7 and 5-HT1A receptors were explained using a conformational analysis. A bioactive conformation of those compounds for the 5-HT7 receptor, different from that established for 5-HT1A, was proposed.

PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES

This invention is directed generally to substituted pyridinone and pyrimidinone compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygeπase activity. Such substituted pyridinone and pyrimidinone compounds include compounds generally corresponding in structure to the following formula: wherein Z, n, R1, R2a, R2b, R2c, R2d, R2e, R3a, R3b R3c, R3d, R4, R5, R6, R7a, R7b, R7c, R7d and R7e are as defined in this specification. This invention also is directed to compositions of such substituted pyridinones and pyrimidinones (particularly pharmaceutical compositions), and methods for treating disorders (typically pathological disorders) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.