1176887-92-5Relevant academic research and scientific papers
Syntheses of quinazolinones from 2-iodobenzamides and enaminones via copper-catalyzed domino reactions
Songsichan, Teerawat,Promsuk, Jaturong,Rukachaisirikul, Vatcharin,Kaeobamrung, Juthanat
supporting information, p. 4571 - 4575 (2014/06/24)
N-Substituted 2-iodobenzamides and enaminones undergo cascade transformations to achieve quinazolinones via a copper-catalyzed Ullmann-type coupling, a Michael addition and a retro-Mannich reaction. A unique stereochemical feature of this domino process was that Z-enaminones reacted without external ligands, whereas E-enaminones required the assistance of ligands. This journal is
Asymmetric synthesis of 4H-1,3-oxazines: Enantioselective reductive cyclization of N-acylated β-amino enones with trichlorosilane catalyzed by chiral Lewis bases
Sugiura, Masaharu,Kumahara, Mako,Nakajima, Makoto
supporting information; experimental part, p. 3585 - 3587 (2009/12/03)
N-Acylated β-amino enones reductively cyclize by treatment with trichlorosilane and a chiral Lewis base catalyst to afford optically active 4H-1,3-oxazines, which can be transformed to other chiral compounds without racemization.
