117704-25-3 Usage
Pig antiparasitic
Doramectin is a new generation of antiparasitic , compared with other commercially available ivermectin products, anti-parasite range of Doramectin is broader, with better effect, and Doramectin can prevent parasite reinfection for a longer valid time, It is the world's best, the most potential anti-parasitic drugs for development veterinary .
Doramectin as a pesticide can kill all the the internal and external parasites , and is also valid to nematodes, arthropods. At present, Chinese pig industry commonly used insecticide drugs include: parasite drugs: albendazole, levamisole, trichlorfon, Vietnam, hygromycin, ivermectin, avermectin. External parasite drugs: trichlorfon, amitraz, diazinon, permethrin drugs, avermectin, ivermectin.
Doramectin has a good effect on pig gastrointestinal nematodes , it is reported that pig is injected 0.3 mg/kg by intramuscular, dosing artificial and natural infection cases after 7 days , 14 days, 21 days, weight gains is significantly higher (swine P <0.0001); compared with the control group, percentage of getting rid of worms is 100%, and there are no side effects.
In Pig scabies mite treatment, from piglets to sows ,Doramectin has good results .After artificial infection scabies mites, according to the body weight ,administrated 0.3 mg/kg intramuscularly, four weeks after the test, the result of inflammation of the skin injury in pigs and worms Elimination of infected body, is very significant (P <0.05). Treatment for pregnant sows kidney worm, press the 0.3 mg/kg dose neck single injection, the 56 day and 57 day of testing, the detection rate of Urine eggs is 0, the percentage of getting rid of them is 100%, while the control group per milliliter of urine displays 3762 eggs. For lung worms, lice and other pigs parasites,it has the same effect.
According to more than l ng/g tissue concentration of the drug having anti-parasitic activity, the drug can be used to assess the validity.
Duration time of Ivermectin is greater than 1 ng/g concentration :18 days for the skin, the lungs 18 days, 18 days for gastrointestinal mucosa, gastric mucosa wrinkled 18 days.
Duration time of Doramectin is greater than 1 ng/g concentration: 26 days for the skin, the lungs 38 days, 38 days for gastrointestinal mucosa, gastric mucosa wrinkled 38 days.
Thus,duration time of more than 1 ng/g doramectin in the gastrointestinal mucosa, lung tissue is 38 days, 20 days more than ivermectin.
So the effect of doramectin to drive and to kill the parasites is stronger than ivermectin, and it can be effective to prevent the parasite reinfection .
The above information is edited by the lookchem of Tian Ye.
Pharmacological effects
[Chemical properties] brown powder , very low solubility in water.
Doramectin is used for the treatment of livestock diseases such as nematodes and mites ectoparasitosis,it is fermented by recombinant avermitilis (Streptomyces avermitilis) new strain, and the main difference from ivermectin is that C25 is substituted by cyclohexyl. It is a new, broad-spectrum antiparasitic drug,and is efficient for gastrointestinal nematodes, lung nematodes, Euglena, lice, ticks, mites and wound maggots , also has a good effect on internal and external parasites especially certain nematodes (round worms) and arthropods , but invalid to tapeworms, flukes and protozoa . Its mechanism of action is to increase the release of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) of the worm, thereby blocking the transmission of nerve signals, so that muscle cells lose their ability to contract, resulting in death of the parasites. the neurotransmitter of Peripheral nerves of mammals is acetylcholine,and will not be affected by Doramectin, doramectin cannot go through the blood-brain barrier easily , minimal damage to the central nervous system,safe to cattle. The main feature is that the plasma concentration and half-life are higher or twice than Ivermectin. The United States has approved to use as cattle, pigs and dedicated injection and cattle dedicated pour.
Precautions
1, doramectin is unstable and decomposes rapidly in the sunlight to be inactivated, its remnants of drugs are toxic to fish and aquatic organisms, so pay attention to water protection.
2, pour-on: bovine application, not rain within 6 hours.
3, use with caution in dogs.
4, the goods will be placed out of reach of children, the operator should not eat or smoking, wash hands after handling.
5, withdrawal period, 35 days of cattle, pigs 24 days.
Description
Doramectin is a novel avermectin with a cyclohexyl
substituent on the previously inaccessible C-25 position
of the molecule; the substitution was facilitated by
mutational biosynthesis. The discovery of doramectin
involved feeding carboxylic acids or their precursors to
a fermentation of Streptomyces avermitilis that lacked
branched-chain 2-oxo acid dehydrogenase activity, and
then screening the resultant fermentation products for
anthelmintic and ectoparasiticidal activity (89).
Two dosage forms of doramectin have been developed
for use as an endectocide on cattle, an injectable
formulation for subcutaneous administration and a pouron
formulation. An injectable formulation is also approved
for use on pigs.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 117704-25-3 differently. You can refer to the following data:
1. antibacterial
2. Doramectin is a biosynthetic avermectin derived from a mutant strain of Streptomyces avermitilis, supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
3. A mutational biosynthetic antiparasitic antibiotic.
4. Mutational biosynthetic antiparasitic antibiotic structurally related to the avermectins
Veterinary Drugs and Treatments
Doramectin injection is indicated for the treatment and control of
the following endo- and ectoparasites in cattle: roundworms (adults
and some fourth stage larvae)—Ostertagia ostertagi
(including inhibited
larvae), O. lyrata, Haemonchus placei, Trichostrongylus axei,
T. colubriformis,
T. longispicularis, Cooperia oncophora, C. pectinata,
C. punctata, C. surnabada (syn. mcmasteri),
Bunostomum phlebotomum,
Strongyloides papillosus, Oesophagostomum radiatum,
Trichuris spp.; lungworms (adults and fourth stage larvae)—Dictyocaulus
viviparus; eyeworms (adults)—Thelazia
spp.; grubs (parasitic
stages)—Hypoderma bovis, H. lineatum; lice—Haematopinus
eurysternus,
Linognathus vituli, Solenopotes capillatus; and mange
mites—Psoroptes bovis, Sarcoptes scabiei.
In swine the injection is labeled for the treatment and control
gastrointestinal roundworms (adults and 4th stage Ascaris suum,
adults and 4th stage Oesophagostomum dentatum, Oesophagostomum
quadrispinolatum adults, Strongyloides ransomi adults, and
Hydrostrongylus rubidus adults), lungworms (Stephanurus dentatus
adults), mange mites (adults and immature stages Sarcoptes
scabeii var. suis), and sucking lice (adults and immature stages
Haematopinus suis)
The manufacturer states the doramectin protects cattle against
infection or reinfection with Ostertagia ostertagi for up to 21 days.
Doramectin topical (pour-on) is approved for use in cattle and
has a similar spectrum of action against a variety of endo- and ectoparasites,
including biting lice.
Injectable doramectin has been used for treating a variety of
nematode and arthropod parasites in companion animals, including
generalized demodicosis in dogs and cats and spirocercosis in
dogs.
Check Digit Verification of cas no
The CAS Registry Mumber 117704-25-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,7,0 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 117704-25:
(8*1)+(7*1)+(6*7)+(5*7)+(4*0)+(3*4)+(2*2)+(1*5)=113
113 % 10 = 3
So 117704-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16-/t27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43-,44?,45-,46?,47+,49+,50+/m0/s1
117704-25-3Relevant articles and documents
Process and antiparasitic intermediates for doramectin
-
, (2008/06/13)
Intermediates and a process for preparing doramectin, the compound of formula (I), semisynthetically from by-product in the fermentation procedure which also yields the compound of formula (I). The intermediates prepared by the process of this invention also have utility as antiparasitic agents. The process of this invention utilizes continuous reaction inert gas sparging during the pyrolysis step, resulting in a significant improvement in the overall yield of this conversion. STR1
