117708-72-2

Upstream product

• 134965-14-3 (5R,6S)-2-Ethyl-5-methyl-6-phenyl-2,4-di-p-tolyl-[1,3]oxazinane 
• 99408-84-1 (2R,5R,6S/2S,5S,6R)-2-ethyl-5,6-dihydro-5-methyl-2,4-bis(4-methylphenyl)-6-phenyl-2H-1,3-oxazine 
• 138356-05-5 3-imino-1,N-diphenyl-2-methyl-3-(p-tolyl)prop-1-enylamine 
• 117708-69-7 (1R,2R,4S)-2-((S)-1-Benzyloxy-ethyl)-5-methyl-1,6-diphenyl-4-p-tolyl-1,2,3,4-tetrahydro-pyrimidine 
• 117596-58-4 (1R,2S)-2-((S)-1-Benzyloxy-ethyl)-5-methyl-1,6-diphenyl-4-p-tolyl-1,2-dihydro-pyrimidine 
• 117708-70-0 (2S,3R)-3-Amino-2-methyl-1-phenyl-3-p-tolyl-propan-1-one 

Relevant academic research and scientific papers

Synthesis of 1,3-amino alcohols from 2-aza-1,3-dienes by reduction of 5,6-dihydro-2H-1,3-oxazines

5,6-Dihydro-2H-1,3-oxazines 3, prepared from 2-aza-1,3-dienes 4, react with sodium in 2-propanol, giving tetrahydro-2H-1,3-oxazines 5. The acid hydrolysis of 5 leads to 1,3-amino alcohols 6 with three stereocenters. The reduction of 3 with lithium aluminum hydride affords N-alkyl derivatives of 1,3-amino alcohols 7 with four stereocenters. The stereochemistry of these compounds was established by X-ray crystallography of (4S*,5S*,6R*)-5-methyl-4,6-diphenyl-3-[(1R*)-1-phenylpropyl]tetra hydro-2H-1,3-oxazine (8).

Diastereo- and Enantio-selective Synthesis of Dihydro- and Tetrahydro-pyrimidines. A New Strategy for the Asymmetric Synthesis of β-Amino Ketones and γ-Amino Alcohols

Chiral 1,2-dihydro- (3) and 1,2,3,6-tetrahydro-pyrimidines (4) have been synthesized by reaction of 3-aminoalk-2-enimines (1) with chiral aldehydes, the structure of (4) being comfirmed by an X-ray crystal structure determination of a reduction product; a

AZADIENE DERIVATIVES AS SYNTHETIC INTERMEDIATES

The applicability 4-amino-1-azabutadienes 1 in synthesis of five-, six-, and eight-membered ring heterocycles is demonstrated; several open-chain compounds have also been diastereo- or enantio-selectively prepared.The synthesis and reactivity of both neut