117709-78-1

Basic information

• Product Name: (2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]henicosa-10,12,14(21),16,18(1),19-hexaene-7-one
• Synonyms: (2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]henicosa-10,12,14(21),16,18(1),19-hexaene-7-one;Combretastatin D1;(2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]heneicosa-10,12,14(21)-16,18,19-hexaen-7-one
• CAS NO: 117709-78-1
• Molecular Formula: C18H16O5
• Molecular Weight: 312.32
• Mol File: 117709-78-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.305
• CAS DataBase Reference: (2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]henicosa-10,12,14(21),16,18(1),19-hexaene-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]henicosa-10,12,14(21),16,18(1),19-hexaene-7-one(117709-78-1)
• EPA Substance Registry System: (2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]henicosa-10,12,14(21),16,18(1),19-hexaene-7-one(117709-78-1)

Safety Data

• Hazardous Substances Data: 117709-78-1(Hazardous Substances Data)

Usage

General Description

The chemical compound (2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]henicosa-10,12,14(21),16,18(1),19-hexaene-7-one is a complex heterocyclic compound with a tetracyclic structure. It contains a hydroxy group at the 13th position and a ketone group at the 7th position. (2S,4R)-13-Hydroxy-3,6,15-trioxatetracyclo[14.2.2.110,14.02,4]henicosa-10,12,14(21),16,18(1),19-hexaene-7-one has a unique and intricate bicyclic ring system, which includes multiple oxygen atoms incorporated into the structure. It is an organic compound that has potential applications in pharmaceuticals, materials science, and organic synthesis due to its complex structure and functional groups. Additional research is necessary to fully understand the potential uses and properties of this compound.

Upstream product

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• 172919-11-8 (13R,14R)-4-Benzyloxy-13,14-bis-(tert-butyl-dimethyl-silanyloxy)-2,11-dioxa-tricyclo[13.2.2.1^3,7]icosa-1⁽¹⁸⁾,3,5,7⁽²⁰⁾,15⁽¹⁹⁾,16-hexaen-10-one 
• 172919-06-1 2,2-Dimethyl-propionic acid (2R,3R)-3-{4-[2-benzyloxy-5-(2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-2,3-dihydroxy-propyl ester 
• 172919-08-3 2,2-Dimethyl-propionic acid (E)-3-{4-[2-benzyloxy-5-(2-ethoxycarbonyl-ethyl)-phenoxy]-phenyl}-allyl ester 
• 172919-05-0 (13R,14R)-4-benzyloxy-13,14-dihydroxy-2,11-dioxatricyclo[13.2.2.1^3,7]eicosa-1⁽¹⁸⁾,3,5,7⁽²⁰⁾,1⁽¹⁹⁾,16-hexaen-10-one 
• 172919-14-1 ethyl 3-(3'-hydroxy-4'-benzyloxyphenyl)propanoate 
• 172919-07-2 2,2-Dimethyl-propionic acid (E)-3-(4-bromo-phenyl)-allyl ester 
• 1122-91-4 4-bromo-benzaldehyde 
• 105515-33-1 (2E)-3-(4-bromophenyl)prop-2-en-1-ol 
• 24393-53-1 ethyl (E)-3-(4-bromophenyl)-2-propenoate 
• 4049-39-2 4-benzyloxy-3-hydroxy-benzaldehyde 
• 172919-12-9 C₂₅H₂₂O₅ 

Relevant articles and documents

Total synthesis of natural (-)combretastatin D-1

Combretastatin D-1, (2), was synthesized via a 12 step sequence. Sharpless asymmetric dihydroxylation was used in order to introduce the appropriate asymmetry. Regiospecific cyclodehydration of the diol 3 gave the title compound in 96% ee.