117710-30-2Relevant academic research and scientific papers
Synthesis and biological evaluation of didemnin photoaffinity analogues
Vera, Matthew D.,Pfizenmayer, Amy J.,Ding, Xiaobin,Ahuja, Deepika,Toogood, Peter L.,Joullie, Madeleine M.
, p. 1871 - 1874 (2007/10/03)
The synthesis of four benzophenone-containing analogues of the antiproliferative natural product didemnin B is presented. In vitro protein biosynthesis inhibition potency and antitumor activity were evaluated. The results indicate that all four analogues are biologically active and could serve as photoaffinity reagents for the study of receptor-binding interactions of didemnins. These analogues could also be useful in studying antitumor effects of didemnins.
Analogs of the β-turn of the cyclodepsipeptide didemnin B
Ramanjulu, Joshi M.,Joullie, Madeleine M.
, p. 311 - 314 (2007/10/02)
Three side chain analogs of didemnin B were synthesized. All three analogs of the only conventional type II β-turn present in didemnin B differed in the functionality incorporated in the threonine residue. The cytotoxic activities of these analogs were evaluated, and one of them exhibited weak activity.
