1177141-67-1

Basic information

• Product Name: N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride
• Synonyms: CKI-7 Dihydrochloride;N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride;CKI-7 dihydrochlorid
• CAS NO: 1177141-67-1
• Molecular Formula: C11H14Cl3N3O2S
• Molecular Weight: 358.67176
• Product Categories: All Inhibitors;Inhibitors;Protein Kinase Inhibitors and Activators
• Mol File: 1177141-67-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 187-189°C
• Appearance: white to light tan/
• Storage Temp.: -20°C Freezer
• Solubility: H2O: >5mg/mL
• CAS DataBase Reference: N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride(1177141-67-1)
• EPA Substance Registry System: N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride(1177141-67-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1177141-67-1(Hazardous Substances Data)

Usage

Description

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride is a chemical compound with potent inhibitory action against casein kinase 1, particularly with respect to ATP, and a weaker effect on casein kinase 2 and other protein kinases. It is a beige solid with potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride is used as a pharmaceutical agent for its inhibitory action against casein kinase 1. Its ability to target this enzyme makes it a promising candidate for the development of drugs to treat diseases associated with abnormal kinase activity.
Used in Research Applications:
In the field of research, N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride is used as a research tool to study the role of casein kinase 1 in various biological processes. Its selective inhibition of this enzyme allows researchers to investigate its function and potential therapeutic targets.
Used in Drug Development:
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride is used in drug development as a lead compound for the creation of new drugs targeting casein kinase 1. Its potent inhibitory action and selectivity make it a valuable starting point for the design and synthesis of novel therapeutic agents.
Used in Chemical Synthesis:
In the chemical synthesis industry, N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride can be used as a building block or intermediate in the synthesis of other related compounds with potential applications in various fields, such as pharmaceuticals, agrochemicals, or materials science.

Biochem/physiol Actions

CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM.