117719-16-1

Basic information

• Product Name: 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE
• Synonyms: 3-morpholinopyrazin-2-amine;3-(4-Morpholinyl)-2-pyrazinamine
• CAS NO: 117719-16-1
• Molecular Formula: C₈H₁₂N₄O
• Molecular Weight: 180.21
• Product Categories: Piperazines
• Mol File: 117719-16-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 383.897 °C at 760 mmHg
• Flash Point: 185.975 °C
• Appearance: /
• Density: 1.274 g/cm³
• Refractive Index: 1.601
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE(117719-16-1)
• EPA Substance Registry System: 2-AMINO-3-MORPHOLIN-4-YLPYRAZINE(117719-16-1)

Safety Data

• Hazardous Substances Data: 117719-16-1(Hazardous Substances Data)

Usage

General Description

2-Amino-3-Morpholin-4-ylpyrazine is a chemical compound whose molecular formula is C8H12N4O. As suggested by its name, this substance includes features such as an amino group and a morpholino group, both of which are connected to a pyrazine ring. Pyrazines are heterocyclic aromatic organic compounds which can contribute to various flavors and odors. The morpholino group meanwhile introduces a cyclic ether with a secondary amine. The chemical properties and uses of 2-Amino-3-Morpholin-4-ylpyrazine are variable and would be dependent on the context in which it is utilized. Information regarding its safety, toxicity and environmental impact are not widely available, indicating that this substance isn't commonly used in industry or research.

InChI:InChI=1/C8H12N4O/c9-7-8(11-2-1-10-7)12-3-5-13-6-4-12/h1-2H,3-6H2,(H2,9,10)

Upstream product

• 1400820-46-3 4-{3-[(triphenyl-λ⁵-phosphanylidene)amino]pyrazin-2-yl}morpholine 
• 110-91-8 morpholine 
• 6863-73-6 3-chloropyrazin-2-amine 

Downstream Products

• 1312550-16-5 N-cyclohexyl-8-morpholino-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine 

Relevant articles and documents

Design and optimization of purine derivatives as in vivo active PDE10A inhibitors

Phosphodiesterases are important enzymes regulating signal transduction mediated by second messenger molecules cAMP or cGMP. PDE10A is a unique member in the PDE family because of its selective expression in medium spiny neurons. It is recognized as anti-psychotic drug target. Based on the structural similarity between our previous chemistry work on 8-aminoimidazo[1,2-a]pyrazines and the PDE10A inhibitors reported by Bartolome-Nebreda et al., we initialized a project for developing PDE10A inhibitors. After several rounds of optimization, we were able to obtain a few compounds with good PDE10A enzymatic activity. And after further PDE enzymatic selectivity study, metabolic stability assay and in vivo pharmacological tests we identified two inhibitors as interesting lead compounds with the potential for further PDE10A lead optimizatioin.

Discovery of a potent, selective, and orally active phosphodiesterase 10A inhibitor for the potential treatment of schizophrenia

We report the discovery of a series of imidazo[1,2-a]pyrazine derivatives as novel inhibitors of phosphodiesterase 10A (PDE10A). In a high-throughput screening campaign we identified the imidazopyrazine derivative 1, a PDE10A inhibitor with limited select

Discovery and application of iminotriphenylphosphorane as a formal aromatic primary amine protecting group

During our efforts to selectively synthesise N-arylated benzotriazole fragments, we developed a new primary aromatic amine protecting group strategy showing significant advantages over recognised protecting groups.