1177252-29-7

Basic information

• Product Name: 1-{(1-benzyl-1H-tetrazol-5-yl)[4-(2-methyl-1,3-thiazol-4-yl)phenyl]methyl}-4-cyclobutyl-1,4-diazepane
• CAS NO: 1177252-29-7
• Molecular Weight: 499.683
• Mol File: 1177252-29-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-{(1-benzyl-1H-tetrazol-5-yl)[4-(2-methyl-1,3-thiazol-4-yl)phenyl]methyl}-4-cyclobutyl-1,4-diazepane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{(1-benzyl-1H-tetrazol-5-yl)[4-(2-methyl-1,3-thiazol-4-yl)phenyl]methyl}-4-cyclobutyl-1,4-diazepane(1177252-29-7)
• EPA Substance Registry System: 1-{(1-benzyl-1H-tetrazol-5-yl)[4-(2-methyl-1,3-thiazol-4-yl)phenyl]methyl}-4-cyclobutyl-1,4-diazepane(1177252-29-7)

Safety Data

• Hazardous Substances Data: 1177252-29-7(Hazardous Substances Data)

Upstream product

• 127406-11-5 4-(2-methyl-thiazol-4-yl)-benzaldehyde 
• 88333-03-3 Benzyl isocyanide 

Relevant articles and documents

Discovery of substituted benzyl tetrazoles as histamine H3 receptor antagonists

A series of potent and subtype selective H3 receptor antagonists containing a novel tetrazole core and diamine motif is reported. A one-pot multi-component Ugi reaction was utilised to rapidly develop the structure-activity relationships (SAR) of these compounds. Optimisation for liver microsome stability (t1/2 >60 min), minimal CYP inhibition (IC50 >50 μM) and high cell permeability (Caco-2 Papp >20 × 10-6 cm/s) identified several compounds with drug-like properties.