1177261-89-0

Upstream product

• 1229578-62-4 3-iodo-5-methoxy-8,8-dimethyl-8H-pyrano[3,2-g]chromone 
• 1399841-47-4 2-imidazol-5-methoxyl-8,8-dimethyl-8H-pyrano-[3,2-g]chromone 
• 120-80-9 benzene-1,2-diol 
• 171021-68-4 4-hydroxy-5-methoxy-8,8-dimethyl-2H,8H-benzo<1,2-b:5,4-b'>-dipyran-2-one 
• 99365-30-7 5-Hydroxy-8,8-dimethyl-8H-pyrano<3,2-g>chromone 
• 1229578-64-6 5-methoxy-8,8-dimethyl-8H-pyrano[3,2-g]chromone 
• 480-66-0 2,4,6-trihydroxyacetophenone 
• 31721-94-5 5,7-dihydroxy-chromen-4-one 
• 99365-29-4 5-hydroxy-7-(1,1-dimethylpropargyloxy)chromone 

Relevant academic research and scientific papers

Synthesis of hirtellanine B, an isoflavonoid with potent antiproliferative effects in cancer cells

We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activity of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells. Copyright

Natural product Hirtellanine B and its derivatives in the preparation process for the preparation of medicine for treating tumor with the application of the

The present invention provides a preparation method of a natural product Hirtellanine B, wherein 2,4,6-trihydroxyacetophenone is adopted as a raw material, and steps of compound a preparation, compound b preparation, compound c preparation, compound d preparation, compound e preparation, compound f preparation, compound g preparation, and the like are performed to prepare the natural product Hirtellanine B. According to the present invention, biological activity screening is performed on Hirtellanine B and 14 Hirtellanine B derivatives, and results show that the natural product Hirtellanine B can inhibit proliferations of Jurkat cells, Raji cells and K562 cells, and the compounds provide a certain inhibition activity for tumor cells. The method has characteristics of easily available raw material, high reaction yield and reasonable operation, and is suitable for industrial production. The Hirtellanine B and the derivatives thereof can be used for preparing tumor treatment drugs, and have great clinical values. The natural product Hirtellanine B preparation method reaction formulas are as the follows.