1177265-06-3Relevant academic research and scientific papers
Regioselective and Transition-Metal-Free Addition of tert -Butyl Magnesium Reagents to Pyridine Derivatives: A Convenient Method for the Synthesis of 3-Substituted 4- tert -Butylpyridine Derivatives
Rappenglück, Sebastian,Niessen, Karin V.,Seeger, Thomas,Worek, Franz,Thiermann, Horst,Wanner, Klaus T.
, p. 4055 - 4064 (2017)
A variety of 3,4-disubstituted pyridine derivatives with a tert -butyl group in the 4-position were synthesized in a transition-metal-free, two-step reaction sequence from 3-substituted pyridine precursors. Highly regioselective addition of t -Bu 2 Mg to TIPS-activated pyridines and an efficient microwave-assisted aromatization with sulfur as oxidant afforded the desired 3,4-disubstituted pyridine derivatives in moderate to excellent yields. The method is compatible with many functional groups such as ester, amide, halide, nitrile or alkyne groups present in the 3-position.
