1177265-11-0Relevant articles and documents
Regioselective addition of organomagnesium reagents to N-silyl activated nicotinic acid esters-a convenient method for the synthesis of 4,4-disubstituted 1,4-dihydronicotinates
Sperger, Christian A.,Wanner, Klaus T.
experimental part, p. 5824 - 5833 (2009/12/03)
The addition of RMgX or R2Mg to nicotinic acid esters, activated with triisopropylsilyl triflate, was investigated. The regioselectivity of this reaction, where 4-unsubstituted and 4-substituted pyridine derivatives were employed as starting ma