1177312-52-5

Basic information

• Product Name: 1-[(4-NITRO-1H-PYRAZOL-1-YL)METHYL]-1H-PYRAZOLE-3-CARBOXYLIC ACID
• Synonyms: 1-(4-Nitro-pyrazol-1-ylmethyl)-1H-pyrazole-3-carboxylic acid;1-[(4-NITRO-1H-PYRAZOL-1-YL)METHYL]-1H-PYRAZOLE-3-CARBOXYLIC ACID
• CAS NO: 1177312-52-5
• Molecular Formula: C8H7N5O4
• Molecular Weight: 237.17
• Mol File: 1177312-52-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(4-NITRO-1H-PYRAZOL-1-YL)METHYL]-1H-PYRAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-NITRO-1H-PYRAZOL-1-YL)METHYL]-1H-PYRAZOLE-3-CARBOXYLIC ACID(1177312-52-5)
• EPA Substance Registry System: 1-[(4-NITRO-1H-PYRAZOL-1-YL)METHYL]-1H-PYRAZOLE-3-CARBOXYLIC ACID(1177312-52-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1177312-52-5(Hazardous Substances Data)

Usage

General Description

1-((4-nitro-1H-pyrazol-1-yl)methyl)-1H-pyrazole-3-carboxylic acid is a chemical compound consisting of a pyrazole core with a carboxylic acid group at position 3 and a 4-nitro-1H-pyrazol-1-ylmethyl group at position 1. 1-((4-nitro-1H-pyrazol-1-yl)methyl)-1H-pyrazole-3-carboxylic acid has the potential to be used in pharmaceutical research due to its structural features, which make it suitable for various applications. The presence of the carboxylic acid group allows for potential modification and derivatization, which can be important for medicinal chemistry research. Additionally, the 4-nitro-1H-pyrazol-1-ylmethyl group may impart specific biological activities or interactions with target molecules, making it a valuable chemical entity for drug discovery and development. Further studies and investigations are needed to fully understand the potential uses and properties of this chemical.

Relevant articles and documents

Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety

Hypoxia-inducible factor 1 (HIF-1) is a promising drug target for cancer chemotherapy. In our screening program aimed at identifying new HIF-1 inhibitors by using a hypoxia-responsive luciferase reporter gene assay, KUSC-5001 containing the 1-alkyl-1H-pyrazole-3-carboxamide moiety was found as a potential hit molecule. During an extensive structure–activity relationship (SAR) study, we developed a more effective HIF-1 inhibitor KUSC-5037 (IC50 = 1.2 μM). Under hypoxic conditions, KUSC-5037 suppressed the HIF-1α (a regulatory subunit of HIF-1) mRNA, causing decreases in the gene expression of HIF-1 target genes such as carbonic anhydrase 9 (CA9) and vascular endothelial growth factor (VEGF) genes. Furthermore, by applying our fluorescent and bifunctional probes, ATP5B, a catalytic β subunit of mitochondrial FoF1-ATP synthase, was identified as a target protein of KUSC-5037. These results indicate that the derivatives of KUSC-5037 containing the 1-alkyl-1H-pyrazole-3-carboxamide moiety are promising lead molecules for the inhibition of HIF-1 signaling via FoF1-ATP synthase suppression.