1177347-71-5Relevant academic research and scientific papers
Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives
George, Riham F.,Saleh, Dalia O.
, p. 663 - 673 (2016/01/09)
Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used reference standard, IC50 = 226 μM), that, they may represent promising hits for treatment of cardiovascular disorders. The observed activity was validated by a statistically significant QSAR model (N = 32, n = 6, R2 = 0.811782, R2cvOO = 0.7153, R2cvMO = 0.7209, F = 17.9708, s2 = 9.65226 × 10-8) that was obtained employing CODESSA-Pro software.
Some new pyrazole and pyrazolopyrimidines: Synthesis and antimicrobial evaluation
Shamroukh, Ahmed H.,Rashad, Aymn E.,Ali, Hatem S.,Abdel-Megeid, Farouk M.E.
, p. 758 - 765 (2013/08/23)
Novel β-enaminonitrile of 1-(6-phenyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using (6-phenyl-pyridazin-3-yl)-hydrazine (1) and 2-ethoxymethylene-malononitrile. The β-enaminonitrile derivative 2 was in turn used as precursors for the preparation
