1177355-91-7

Upstream product

• 38956-80-8 3-hydrazino-6-phenylpyridazine 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 

Downstream Products

• 1649475-10-4 N-[6-methyl-4-oxo-1-(6-phenyl-pyridazin-3-yl)-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-yl]acetamide 
• 1649475-12-6 [5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazol-4-yl]-(3,5-dimethylpyrazol-1-yl)-methanone 
• 1649475-14-8 [5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazol-4-yl]-(5-amino-4-cyano-pyrazol-1-yl)methanone 
• 1649475-22-8 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carboxylic acid benzylidenehydrazide 
• 1649475-24-0 C₂₁H₁₄N₈O 
• 1649475-26-2 5-(benzylideneamino)-1-(6-phenylpyridazin-3-yl)-1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one 
• 1649475-28-4 4-(5-phenyl-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-2-(6-phenylpyridazin-3-yl)-2H-pyrazole-3-ylamine 
• 1649475-30-8 4-(5-phenyl-[1,3,4]oxadiazol-2-yl)-2-(6-phenyl-pyridazin-3-yl)-2H-pyrazole-3-ylamine 
• 1649475-06-8 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carboxylic acid hydrazide 
• 1649475-08-0 5-amino-1-(6-phenyl-pyridazin-3-yl )-1H-pyrazole - 4-carbonylazide 
• 1649475-09-1 C₁₈H₁₅N₇O₂ 

Relevant academic research and scientific papers

Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives

Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used reference standard, IC50 = 226 μM), that, they may represent promising hits for treatment of cardiovascular disorders. The observed activity was validated by a statistically significant QSAR model (N = 32, n = 6, R2 = 0.811782, R2cvOO = 0.7153, R2cvMO = 0.7209, F = 17.9708, s2 = 9.65226 × 10-8) that was obtained employing CODESSA-Pro software.

Studies on the reactivity of amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole- 4-carboxylic acid hydrazide towards some reagents for biological evaluation

Novel 5-amino-1-(6-phenyl-pyridazin-3-yl)-1H-pyrazole-4-carboxylic acid ethyl ester (2) was formed using (6-phenyl-pyridazin-3-yl)-hydrazine (1) and ethyl(ethoxymethylene)cyanoacetate. The β-enaminoester derivative 2 was in turn used as precursor for the