117736-74-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(Methylthio)-1H-pyrazol-5-amine is used as a reagent for the synthesis and evaluation of 2-(α-arylalkylamino)-4-(pyrazolylamino)pyrimidines. These compounds are potent inhibitors of Trk kinases, which play a crucial role in the development and progression of various cancers. By inhibiting Trk kinases, these pyrimidine-based inhibitors can potentially be used as therapeutic agents for the treatment of cancer.
In addition to their application in cancer research, 3-(Methylthio)-1H-pyrazol-5-amine and its derivatives may also find use in other areas of pharmaceutical development, such as the synthesis of novel drugs targeting other kinases or enzymes involved in various diseases.
Used in Agrochemical Industry:
Although not explicitly mentioned in the provided materials, 3-(Methylthio)-1H-pyrazol-5-amine and its derivatives may also have potential applications in the agrochemical industry. Given its reactivity and ability to form various chemical structures, it could be used in the development of new pesticides, herbicides, or other agrochemicals that target specific pests or weeds while minimizing harm to the environment and non-target organisms.

Upstream product

• 51245-80-8 3,3-bis(methylthio)-2-propenenitrile 
• 54417-51-5 ethyl 5?amino?3?(methylthio)?1H?pyrazole?4?carboxylate 

Relevant academic research and scientific papers

1H-PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS FOR INHIBITING RAF KINASE

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [FORMULA I]

RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF

Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment

PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS

Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases

The design, synthesis and biological evaluation of a series of 4-aminopyrazolylpyrimidines as potent Trk kinase inhibitors is reported. High-throughput screening identified a promising hit in the 4- aminopyrazolylpyrimidine chemotype. Initial optimization of the series led to more potent Trk inhibitors. Further optimization using two strategies resulted in significant improvement of physical properties and led to the discovery of 10z (AZ-23), a potent, orally bioavailable Trk A/B inhibitor. The compound offers the potential to test the hypothesis that modulation of Trk activity will be of benefit in the treatment of cancer and other indications in vivo.

PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES

Compounds of formula (I): and their use in the inhibition of Trk activity are described.