117738-78-0

Basic information

• Product Name: 4-azido-3,5-dichlorobenzoic acid
• Synonyms: 4-azido-3,5-dichlorobenzoic acid
• CAS NO: 117738-78-0
• Molecular Weight: 232.026
• Mol File: 117738-78-0.mol

Chemical Properties

• CAS DataBase Reference: 4-azido-3,5-dichlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-azido-3,5-dichlorobenzoic acid(117738-78-0)
• EPA Substance Registry System: 4-azido-3,5-dichlorobenzoic acid(117738-78-0)

Safety Data

• Hazardous Substances Data: 117738-78-0(Hazardous Substances Data)

Upstream product

• 56961-25-2 4-amino-3,5-dichlorobenzoic acid 

Relevant articles and documents

Synthesis of Azaylide-Based Amphiphiles by the Staudinger Reaction

Catalyst- and reagent-free reactions are powerful tools creating various functional molecules and materials. However, such chemical bonds are usually hydrolysable or require specific functional groups, which limits their use in aqueous media. Herein, we report the development of new amphiphiles through the Staudinger reaction. Simple mixing of chlorinated aryl azide with a hydrophilic moiety and various triarylphosphines (PAr3) gave rise to azaylide-based amphiphiles NPAr3, rapidly and quantitatively. The obtained NPAr3 formed ca. 2 nm-sized spherical aggregates (NPAr3)n in water. The hydrolysis of NPAr3 was significantly suppressed as compared with those of non-chlorinated amphiphiles nNPAr3. Computational studies revealed that the stability is mainly governed by the decrease in LUMO around the phosphorus atom owing to the o-substituted halogen groups. Furthermore, hydrophobic dyes such as Nile red and BODIPY were encapsulated by the spherical aggregates (NPAr3)n in water.

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

Efficient formation of water- and air-stable aza-ylides has been achieved using the Staudinger reaction between electron-deficient aromatic azides such as 2,6-dichlorophenyl azide and triarylphosphines. The reaction proceeds rapidly and has been successfully applied to chemical modification of proteins in living cells.

Pesticidal compounds

Bicyclooctane pesticides of the formula are prepared by cyclisation of In these formulae R may be various organic groups and is preferably n-butyl or n-propyl while R2 is a polysubstituted phenyl group.