1177408-19-3Relevant academic research and scientific papers
Acyl Radicals from Terminal Alkynes: Photoredox-Catalyzed Acylation of Heteroarenes
Sultan, Shaista,Rizvi, Masood Ahmad,Kumar, Jaswant,Shah, Bhahwal Ali
supporting information, p. 10617 - 10620 (2018/07/31)
A photoredox-mediated acylation reaction of electron deficient heteroarenes with terminal alkynes is reported. The method relies on oxidative cleavage of phenylacetylenes for generation of acyl radicals as a key enabling feature. The reaction is regiosele
Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor
Reux, Bastien,Nevalainen, Tapio,Raitio, Katri H.,Koskinen, Ari M.P.
experimental part, p. 4441 - 4447 (2009/11/30)
A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPγS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.
