117741-11-4

Upstream product

• 591-17-3 meta-bromotoluene 
• 5852-90-4 carbostyril; potassium-salt 
• 769968-22-1 (2E)-N-(3-methylphenyl)-3-phenylprop-2-enamide 

Relevant academic research and scientific papers

Visible-Light-Photocatalyzed Synthesis of Phenanthridinones and Quinolinones via Direct Oxidative C-H Amidation

A straightforward synthetic strategy to construct biologically relevant phenanthridinones and quinolinones was developed via visible-light-promoted direct oxidative C-H amidation. In this photocatalytic system, amidyl radicals can be generated by homolysis of the N-H bond of simple amide precursors via single-electron transfer under blue LED illumination, which leads to oxidative intramolecular C-H amidation. Moreover, an efficient synthetic strategy using a photocascade enabled facile assembly of quinolinone structures through a catalytic sequence involving triplet energy (ET) transfer-based E/Z olefin isomerization and subsequent photocatalytic generation of amidyl radical intermediates.

Preparation and Proton Spectra of 1-Aryl-1,2-dihydro-2-quinolones

1-Phenyl, 1-m-tolyl-, and 1-p-tolyl-1,2-dihydro-2-quinolone have been prepared by treating the potassium derivative of 1,2-dihydro-2-quinolone with the corresponding aryl bromide in the presence of finely divided copper.The use of o-bromotoluene in this reaction gave trace amounts of a crystalline material which upon the basis of mass spectrum analysis was assigned 2-o-tolyloxyquinoline as a structure.The 1-aryl groups caused an unusual chemical shift of 8-proton to the δ 6.64-6.70 region.This behavior paralleled that observed for the 7-proton of 6-phenyl-6H-indenoisoquinoline-5,11-dione in earlier studies.