1177429-77-4Relevant academic research and scientific papers
Synthesis and l-fucosidase inhibitory activity of a new series of cyclic sugar imines-in situ formation and assay of their saturated counterparts
Behr, Jean-Bernard
, p. 4498 - 4501 (2009)
The synthesis of a series of aryl-substituted cyclic sugar imines was performed via a tandem nucleophilic addition/substitution reaction. The so-obtained ketimines displayed fucosidase inhibitory activities (IC50 = 46-556 μM). Their reduced counterparts were prepared and assayed after addition of sodium borohydride to the enzymatic assay stock solution. The pyrrolidines strongly inhibit fucosidase (IC50 = 0.65-150 μM).
