117745-73-0Relevant academic research and scientific papers
Microwave Oriented Solid Support Synthesis of Novel 5,6-Disubstituted-1,2,4-Triazolopyrimidines as Antifungal Agents
Bala, Anju,Gumber, Khushbu,Sidhu, Anjali,Sidhu, Navjot Kaur
, p. 39 - 46 (2021/06/12)
Microwave oriented, basic solid support assisted, two-step reaction of aryl aldehyde, active methylene compounds, and 3-amino-1,2,4-triazole yielded 5,6-disubstituted-1,2,4-triazolopyrimidines in excellent yield without side products, in short reaction time. The preliminary in vitro antifungal evaluation of the compounds indicated the promising antifungal potential of the synthesized compounds against most of the test fungi using standard fungicides as a positive control. The in silico analysis of the synthesized molecules favors the results of in vitro analysis.
Unmodified nano-powder magnetite or iron(III) oxide catalyze the easy and fast synthesis of 4-substituted-4H-pyrans
Cano, Rafael,Ramón, Diego J.,Yus, Miguel
experimental part, p. 2017 - 2020 (2011/10/08)
Inexpensive and commercially available nano-power magnetite or iron(III) oxide can be used as catalyst in a new, straightforward, and fast protocol for the construction of 4-substituted-4H-pyrans. The reaction implies a tandem process, involving an aldol
