117750-31-9Relevant academic research and scientific papers
Dication C(R1)-N(R2)2 synthons and their use in the synthesis of formamidines, amidines, and α-aminonitriles
Cai, Lisheng,Han, Ying,Ren, Sumei,Huang, Liangfu
, p. 8253 - 8262 (2000)
A combination of amides and 2-pyridinesulfonyl chloride was evaluated as synthons of the dication C(R1)-N(R2)2/2+. When the substrates were primary amines, high yields of formamidines and amidines were obtained. When the substrates were α-aminoamides, α-aminonitriles were obtained. Through this process, naturally occurring α-aminoacids can be transformed into chiral α-aminonitriles with complete retention of stereochemical configuration. All reactions proceed rapidly at room temperature, and normally finish within 10 min, with yields ranging from 80 to 95% for most cases. Among the sulfonyl chlorides examined, 2-pyridinesulfonyl chloride stands out in both reaction rate and selectivity of formamidine or amidine versus sulfonyl amide. The scope and limitations of the reaction among different types of amides as synthons and amines as substrates were examined. (C) 2000 Elsevier Science Ltd.
PyBroP: A convenient activator for the synthesis of formamidines
Delarue, Sandrine,Sergheraert, Christian
, p. 5487 - 5490 (1999)
PyBroP was used as a convenient coupling reagent in the synthesis of formamidines from aliphatic and aromatic primary amines and N,N- dimethylformamide.
Efficient synthesis of 2-functionalized benzoxazoles catalyzed by copper iodide
Cao, Han,Liu, Xue-Jing,Bie, Fu-Sheng,Yan, Peng,Ma, Jie,Shi, Yi-Jun,Han, Ying
, p. 1218 - 1232 (2020/10/26)
We reported an efficient synthesis of 2-functionalized benzoxazoles in mild condition and excellent yields. The synthetic process includes two steps. The step one contains a reaction of pendent halide formamidine derivatives and 2-aryloxyacetyl chloride generating highly selective (Z)-N-(2-halophenyl)-3-(dimethylamino)-2-aryloxyacrylamides, and the step two undergoes copper iodide catalyzed intramolecular C-O bond formation to yield title compounds. This strategy is not only providing newly discovered key intermediates 6a-l which contain multiple functional groups on 2-position (as building blocks), but also expanded the scope of methodologies for making diverse benzoxazoles with multiple functional groups.
An efficient and convenient synthesis of formamidines
Han, Ying,Cai, Lisheng
, p. 5423 - 5426 (2007/10/03)
A set of new reagents, aryl sulfonyl chlorides, were used as coupling agents in the syntheses of formamidines from primary amines and N,N-dimethyl formamide in excellent yields.
