117751-72-1Relevant academic research and scientific papers
Total synthesis of the Bacteroides fragilis zwitterionic polysaccharide a1 repeating unit
Pragani, Rajan,Seeberger, Peter H.
scheme or table, p. 102 - 107 (2011/03/17)
Nearly all bacteria capsular polysaccharides are T-cell-independent antigens that do not promote immunoglobulin class switching from IgM to IgG nor memory responses. In contrast, zwitterionic polysaccharides activate T-cell-dependent immune responses by m
De novo synthesis of a 2-acetamido-4amino-2,4,6-trideoxy-d-galactose (AAT) building block for the preparation of a bacteroides fragilis a1 polysaccharide fragment
Pragani, Rajan,Stallforth, Pierre,Seeberger, Peter H.
supporting information; experimental part, p. 1624 - 1627 (2010/06/17)
(Figure Presented) Zwitterionic polysaccharides (ZPSs) are potent T-cell activators that naturally occur on the cell surface of bacteria and show potential as immunostimulatory agents. An unusual, yet important component of many ZPSs is 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT). AAT building block 2 was prepared via a de novo synthesis from N-Cbz-L-threonine 5. Furthermore, building block 2 was used to synthesize disaccharide 15 that constitutes a fragment of zwitterionic polysaccharide A1 (PS A1) found in Bacteroldes fragilis.
An Extremely Powerful Acylation Reaction of Alcohols with Acid Anhydrides Catalyzed by Trimethylsilyl Trifluoromethanesulfonate
Procopiou, Panayiotis A.,Baugh, Simon P.D.,Flack, Stephen S.,Inglis, Graham G.A.
, p. 2342 - 2347 (2007/10/03)
Trimethylsilyl trifluoromethanesulfonate is an excellent catalyst for the acylation of alcohols with acid anhydrides. Highly functionalized primary, secondary, tertiary, and allylic alcohols, and phenols, were acylated cleanly and efficiently and in a fraction of the time used under the standard DMAP conditions.
