117755-94-9 Usage
General Description
CHEMBRDG-BB 4140259 is a chemical compound with the molecular formula C23H28N2O5S. It is a member of the benzimidazole family and is known for its potential antidiabetic and hypolipidemic properties. CHEMBRDG-BB 4140259 has been studied for its ability to regulate glucose and lipid metabolism, making it a promising candidate for the treatment of diabetes and related metabolic disorders. Its mechanism of action involves modulating various metabolic pathways and targets in the body, leading to improved insulin sensitivity and lipid profile. Further research is needed to fully understand its therapeutic potential and safety profile.
Check Digit Verification of cas no
The CAS Registry Mumber 117755-94-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,7,7,5 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 117755-94:
(8*1)+(7*1)+(6*7)+(5*7)+(4*5)+(3*5)+(2*9)+(1*4)=149
149 % 10 = 9
So 117755-94-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO2/c1-8-4-6-9(7-5-8)12-11(2,3)10(13)14/h4-7,12H,1-3H3,(H,13,14)
117755-94-9Relevant articles and documents
Synthesis of androgen receptor antagonists containing a pentafluorosulfanyl (SF5) moiety
Jin, Jiyu,Zhou, Yan,Yang, Dehua,Zhang, Qiumeng,Wang, Ming-Wei,Lu, Wei
, (2018/10/24)
A novel scaffold of pentafluorosulfanyl (SF5)-containing enzalutamide analogues was discovered for potent androgen receptor (AR) antagonists through rational drug design. Several compounds showed good biological profiles in AR binding. Of the derivatives studied, compound 8a had potent AR antagonist activity (IC50 = 7.1 ± 1.0 μM) and high efficacy (104.5 ± 12.8%). It exhibited an inhibitory effect comparable to that of enzalutamide (inhibition = 66.0 and 77.9%, respectively) in a prostate cancer cell line. The results point to the potential of using this scaffold to develop new AR antagonists.
