1177675-11-4

Upstream product

• 515875-85-1 tert-butyl (2-(2-(2-((4,6-dichloro-1,3,5-triazin-2-yl)amino)ethoxy)ethoxy)ethyl)carbamate 
• 123324-71-0 p-tert-butylphenylboronic acid 
• 140-75-0 para-fluorobenzylamine 
• 153086-78-3 tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate 

Relevant academic research and scientific papers

Combinatorial solid-phase synthesis of 6-aryl-1,3,5-triazines via suzuki coupling

A synthetic methodology to prepare collections of trisubstituted aryl 1,3,5-triazines with broad structural diversity via Suzuki coupling has been developed. We first optimized the combinatorial derivatization of the triazine core using Suzuki cross-coupling. Second, in order to further expand the methodology for the preparation of negatively charged triazines, we adapted this approach to polymer-supported amino acids and prepared aryl triazines with different charge distribution. With a collection of 160 aryl triazine derivatives in good purities and without any purification step, we proved the viability of this orthogonal scheme for the preparation of triazine libraries using amine/amino acid-captured solid supports and Suzuki cross-coupling. CSIRO 2011.