117828-49-6Relevant academic research and scientific papers
Biomimetic photocycloaddition of 3-hydroxyflavones: Synthesis and evaluation of rocaglate derivatives as inhibitors of eukaryotic translation
Roche, Stéphane P.,Cencic, Regina,Pelletier, Jerry,Porco Jr., John A.
, p. 6533 - 6538 (2010)
Shedding light on translation: A light-driven, biomimetic [3+2] cycloaddition has been achieved with the synthesis of a series of rocaglate derivatives. Mechanistic data suggest the possibility for donor-acceptor interactions and the involvement of triple
A Synthetic Approach to Rocaglamide via Reductive Cyclization of δ-Keto Nitriles
Kraus, George A.,Sy, James O.
, p. 77 - 83 (2007/10/02)
The anticancer agent rocaglamide contains a novel bicyclooctanol structure.The approach to this molecule involved the preparation of a hydroxy ketone intermediate via a samarium-mediated cyclization.This ketone was then converted into an excellent
