1178555-52-6Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF 6-ALPHA-FLUORO PREGNANES
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Paragraph 0033; 0034, (2014/07/08)
Disclosed is a process for the preparation of 6-α-fluoro pregnanes of formula I wherein R1 is an acyl group, R2 can be H, alpha methyl or beta methyl, and the dotted line can represent a double bond, comprising fluorination with electrophilic fluorinating agents in the 6 position of compounds of formula III, wherein R1, R2 and the dotted line have the meanings stated above, in an inert solvent, in the presence of a basic catalyst at temperatures ranging between 0 and 30° C.
