1178561-48-2Relevant academic research and scientific papers
Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators
Chignen Possi, Kelvine,Mulumba, Mukandila,Omri, Samy,Garcia-Ramos, Yesica,Tahiri, Houda,Chemtob, Sylvain,Ong, Huy,Lubell, William D.
, p. 9263 - 9274 (2017/11/30)
Azapeptide analogues of growth hormone releasing peptide-6 (GHRP-6) exhibit promising affinity, selectivity, and modulator activity on the cluster of differentiation 36 receptor (CD36). For example, [A1, azaF4]- and [azaY4
Exploring side-chain diversity by Submonomer solid-phase aza-peptide synthesis
Sabatino, David,Proulx, Caroline,Klocek, Sophie,Bourguet, Carine B.,Boeglin, Damien,Ong, Huy,Lubell, William D.
supporting information; experimental part, p. 3650 - 3653 (2011/02/25)
Image Presented Submonomer synthesis of aza-peptides featuring regioselective alkylation of peptide-bound aza-Gly residues provided ten aza-analogues of the Growth Hormone Releasing Peptide-6 (GHRP-6) in 15-42% yield and purity generally g90%. Circular dichroism demonstrated that azaPhe-peptide 7a induced a β-turn conformation which may be responsible for its 1000-fold improvement in GHRP-6 selectivity for the CD36 receptor. This versatile method for making aza-peptides avoids solution-phase hydrazine synthesis and is well suited for studying side-chain-activity relationships of biologically active peptides.
