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1178564-45-8

3-(1-methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-2,5-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1178564-45-8 Structure

  • Basic information

    1. Product Name: 3-(1-methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-2,5-dione
    2. Synonyms: 3-(1-methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-2,5-dione
    3. CAS NO:1178564-45-8
    4. Molecular Formula:
    5. Molecular Weight: 528.573
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1178564-45-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(1-methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-2,5-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(1-methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-2,5-dione(1178564-45-8)
    11. EPA Substance Registry System: 3-(1-methyl-1H-indol-3-yl)-1-phenyl-4-(1-(3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-pyrrole-2,5-dione(1178564-45-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1178564-45-8(Hazardous Substances Data)

1178564-45-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1178564-45-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,8,5,6 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1178564-45:
(9*1)+(8*1)+(7*7)+(6*8)+(5*5)+(4*6)+(3*4)+(2*4)+(1*5)=188
188 % 10 = 8
So 1178564-45-8 is a valid CAS Registry Number.

1178564-45-8Downstream Products

1178564-45-8Relevant articles and documents

Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors

Liu, Xiaoqi,Hu, Yuanyuan,Gao, Anhui,Xu, Meng,Gao, Lixin,Xu, Lei,Zhou, Yubo,Gao, Jianrong,Ye, Qing,Li, Jia

, p. 589 - 603 (2019/01/04)

A series of 3-aryl-4-indolylmaleimide IDH1/R132H inhibitors with a novel structure was obtained by high-throughput screening and structure-based optimization. Most compounds such as 7a, 7d, 7h, 7i, 7k and 7o showed high inhibitory effects on IDH1/R132H and were highly selective against IDH1/WT, IDH2/WT, GDH, GK, and FBP. Evaluation of the biological activities and function at cellular level showed that compounds 7h, 7i and 7k could effectively suppress the production of 2-hydroxyglutaric acid in U87MG cells expressing IDH1/R132H. Additionally, 7h could reversed the differentiation block of the myeloid leukemic cell line, TF-1, caused by the overexpression of IDH1/R132H. We also explore the structure-activity relationship based on the experimental data, with an attempt to pave the way for future studies.

Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors

Ye, Qing,Cao, Ji,Zhou, Xinglu,Lv, Dan,He, Qiaojun,Yang, Bo,Hu, Yongzhou

experimental part, p. 4763 - 4772 (2009/11/30)

A series of novel 7-azaindazolyl-indolyl-maleimides were synthesized and evaluated for their antiproliferative activity in vitro against various human cancer cell lines and protein kinase C inhibitory activity. Compounds 8a-c, 8e and 14a were the most pro

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