117857-80-4

Upstream product

• 133342-85-5 (5S)-(2Z-oct-2-en-1-yl)-2-oxo-1,3-dioxolane-(4R)-(5Z,7E,9E)-deca-5,7,9-trienoate de methyle 
• 157872-90-7 (5Z,7E,9E)-10-[(4R,5S)-2,2-Dimethyl-5-((Z)-oct-2-enyl)-[1,3]dioxolan-4-yl]-deca-5,7,9-trienoic acid methyl ester 
• 188740-10-5 (5Z,7E,9E,14Z)-(11R,12S)-11,12-Bis-(tert-butyl-dimethyl-silanyloxy)-icosa-5,7,9,14-tetraenoic acid 
• 188740-07-0 2(S)-<1'(S)-hydroxy-3'(Z)-nonenyl>-3(S)-(trimethylsilyl)oxirane 
• 94889-92-6 methyl 6-iodo-5Z-hexenoate 
• 188740-09-2 (3E,8Z)-(5R,6S)-5,6-Bis-(tert-butyl-dimethyl-silanyloxy)-tetradeca-3,8-dien-1-yne 
• 188740-08-1 (3E,8Z)-(5R,6S)-Tetradeca-3,8-dien-1-yne-5,6-diol 
• 127275-03-0 (Z)-(2S,3S)-2,3-dihydroxy-2,3-O-isopropylidene-5-undecenal 
• 157872-88-3 (2E,4E)-5-[(4R,5S)-2,2-Dimethyl-5-((Z)-oct-2-enyl)-[1,3]dioxolan-4-yl]-penta-2,4-dienal 
• 157872-87-2 (4S,5S,4'R)-2,2,2',2'-Tetramethyl-5-((Z)-oct-2-enyl)-[4,4']bi[[1,3]dioxolanyl] 
• 157966-41-1 (Z)-(1R,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-dec-4-en-1-ol 
• 157872-89-4 (5Z,7E,9E)-10-[(4R,5S)-2,2-Dimethyl-5-((Z)-oct-2-enyl)-[1,3]dioxolan-4-yl]-deca-5,7,9-trienoic acid 
• 133359-69-0 (5R)-<5-hydroxy-(1E,3E)-penta-1,3-dien-1-yl>-(4S)-(2Z-oct-2-en-1-yl)-2-oxo-1,3-dioxolane 
• 133342-84-4 (5R)-<5-oxo-(1E,3E)-penta-1,3-dien-1-yl>-(4S)-(2Z-oct-2-en-1-yl)-2-oxo-1,3-dioxolane 

Relevant academic research and scientific papers

Stereoselective synthesis of (11R, 12S)-(5Z,7E,9E,14Z)-11, 12-dihydroxy-5,7,9,14-eicosatetraenoic acid from 'Diacetone Glucose'

A stereoselective total synthesis of (11R,12S)-diHETE is described. The strategy is based on the use of a 'sugar' derived 'chiron' for the incorporation of vic-diol' stereocentres, while Wittig reactions for the assembly of requisite carbon frame work of the target molecule.

Epoxide ring opening of α,β-epoxysilanes with prop-2-ynyl sulfide dianion - Synthesis of (11R,12S,5Z,7E,9E,14Z)-dihydroxyeicosa-5,7,9,14-tetraenoic acid

A new methodology for synthesis of lipoxygenase metabolites possessing vic-diol substructures coupled with the conjugated alkene system is developed and successfully applied to the synthesis of (11R,12S,5Z,7E,9E,14Z)-dihydroxyeicosa-5,7,9,14-tetraenoic ac

Total synthesis of (5R,6S)-, (5S,6S)- and (11R,12S)- DIHETEs from tricarbonyl(η4-butadienyl) iron(0) complexes.

The total synthesis of (5R,6S)-, (5S,6S)-, and (11R,12S)-DIHETEs are described starting from the two chiral tricarbonyl (η4-butadienyl)iron complexes (-)-(2R,5S)-12 and (+)-(2S,5R)-13.This new synthetic approach shows an efficient use of these

TOTAL SYNTHESIS OF (11R,12S)-diHETE

The first total synthesis of (11R,12S) diHETE is reported.The key step is the highly chemio- and stereoselective osmylation of a double bond in a trienyne system selectively complexed by an Fe(CO)3 group.