1178858-85-9Relevant academic research and scientific papers
N-O-isopropyl sulfonamido-based hydroxamates: Design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis
Nuti, Elisa,Casalini, Francesca,Avramova, Stanislava I.,Santamaria, Salvatore,Cercignani, Giovanni,Marinelli, Luciana,La Pietra, Valeria,Novellino, Ettore,Orlandini, Elisabetta,Nencetti, Susanna,Tuccinardi, Tiziano,Martinelli, Adriano,Lim, Ngee-Han,Visse, Robert,Nagase, Hideaki,Rossello, Armando
experimental part, p. 4757 - 4773 (2010/03/02)
Matrix metalloproteinase-13 (MMP-13) is a key enzyme implicated in the degradation of the extracellular matrix in osteoarthritis (OA). For this reason, MMP-13 synthetic inhibitors are being sought as potential therapeutic agents to prevent cartilage degra
