1178873-45-4

Basic information

• Product Name: tert-butyl 4-({(2E)-4-[(2-amino-5-fluorobenzoyl)amino]but-2-en-1-yl}oxy)benzoate
• Synonyms: tert-butyl 4-({(2E)-4-[(2-amino-5-fluorobenzoyl)amino]but-2-en-1-yl}oxy)benzoate
• CAS NO: 1178873-45-4
• Molecular Weight: 400.45
• Mol File: 1178873-45-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-({(2E)-4-[(2-amino-5-fluorobenzoyl)amino]but-2-en-1-yl}oxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-({(2E)-4-[(2-amino-5-fluorobenzoyl)amino]but-2-en-1-yl}oxy)benzoate(1178873-45-4)
• EPA Substance Registry System: tert-butyl 4-({(2E)-4-[(2-amino-5-fluorobenzoyl)amino]but-2-en-1-yl}oxy)benzoate(1178873-45-4)

Safety Data

• Hazardous Substances Data: 1178873-45-4(Hazardous Substances Data)

Upstream product

• 1178873-44-3 tert-butyl 4-{[(2E)-4-aminobut-2-en-1-yl]oxy}benzoate 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 1178873-47-6 tert-butyl 4-{[(2E)-4-({2-[(diphenylmethyl)amino]-5-fluorobenzoyl}amino)but-2-en-1-yl]oxy}benzoate 

Relevant articles and documents

Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties

The synthesis and optimization of a class of trisubstituted quinazoline-2,4(1H,3H)-dione cPLA2α inhibitors are described. Utilizing pharmacophores that were found to be important in our indole series, we discovered inhibitors with reduced lipophilicity and improved aqueous solubility. These compounds are active in whole blood assays, and cell-based assay results indicate that prevention of arachidonic acid release arises from selective cPLA2α inhibition.