117888-79-6

Basic information

• Product Name: (R)-2-Amino-3-(4-hydroxyphenyl)propanamide hydrochloride
• Synonyms: H-D-Tyr-NH2?HCl; D-Tyrosine-amide hydrochloride hydrate; D-Tyrosine amide hydrochloride; (R)-2-Amino-3-(4-hydroxyphenyl)propanamidehydrochloride
• CAS NO: 117888-79-6
• Molecular Formula: C₉H₁₂N₂O₂*ClH
• Molecular Weight: 216.66742
• Mol File: 117888-79-6.mol
• Article Data: 2

Chemical Properties

• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-2-Amino-3-(4-hydroxyphenyl)propanamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Amino-3-(4-hydroxyphenyl)propanamide hydrochloride(117888-79-6)
• EPA Substance Registry System: (R)-2-Amino-3-(4-hydroxyphenyl)propanamide hydrochloride(117888-79-6)

Safety Data

• Hazardous Substances Data: 117888-79-6(Hazardous Substances Data)

Usage

General Description

(R)-2-Amino-3-(4-hydroxyphenyl)propanamide hydrochloride is a chemical compound primarily used in the research and development of pharmaceuticals. It is a derivative of L-DOPA, an amino acid that is converted to dopamine in the brain. The hydrochloride form of this compound is commonly used in medicinal chemistry studies as a potential treatment for neurodegenerative diseases such as Parkinson's disease. (R)-2-Amino-3-(4-hydroxyphenyl)propanamide hydrochloride has also been studied for its potential antioxidant and neuroprotective properties, making it a promising candidate for future drug development in the treatment of neurological disorders.

Upstream product

• 16870-43-2 L-tyrosine hydrochloride 
• 60-18-4 L-tyrosine 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 3978-80-1 Boc-Tyr-OH 

Downstream Products

• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 17263-42-2 benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 
• 1593627-69-0 C₂₇H₃₃N₄O₄⁽¹⁺⁾*I^(1-) 
• 1593627-67-8 C₁₇H₂₅ClN₂O₄ 
• 1150315-18-6 creatinyl-tyrosine amide 
• 80621-93-8 sarcosyl-tyrosine amide trifluoracetate 
• 80621-91-6 tert-butyloxycarbonyl-sarcosyl-tyrosine amide 
• 74158-36-4 (S)-2-(2-tert-Butoxycarbonylamino-acryloylamino)-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 74158-42-2 (3S,9S,12S)-6-Hydroxy-9-(4-hydroxy-benzyl)-12-isopropyl-3,6-dimethyl-1-oxa-4,7,10-triaza-cyclododecane-2,5,8,11-tetraone 
• 74872-75-6 (S)-2-(2-Oxo-propionylamino)-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 74872-74-5 (S)-2-Amino-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 121637-84-1 Phosphoric acid benzotriazol-1-yl ester 4-{(S)-2-carbamoyl-2-[(S)-2-(2-nitro-phenylsulfanylamino)-3-phenyl-propionylamino]-ethyl}-phenyl ester 2-chloro-phenyl ester 
• 100304-62-9 H-Tyr-D-Arg-Phe-Gly-Tyr-NH₂ 

Relevant articles and documents

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

Increased Gram-negative bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bacteria that is considered as an interesting drug target. ClpP function is involved in protein turnover and homeostasis, stress response, and virulence among other processes. The focus of this study was to identify new inhibitors of Escherichia coli ClpP and to understand their mode of action. A focused library of serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and a chemical exploration around the hit compounds was conducted. Altogether, 14 new potent inhibitors of E. coli ClpP were identified. Compounds 85 and 92 emerged as most interesting compounds from this study due to their potency and, respectively, to its moderate but consistent antibacterial properties as well as the favorable cytotoxicity profile.