117888-80-9

Basic information

• Product Name: (RS)-tyrosinamide hydrochloride
• Synonyms: (RS)-tyrosinamide hydrochloride
• CAS NO: 117888-80-9
• Molecular Weight: 216.667
• Mol File: 117888-80-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (RS)-tyrosinamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-tyrosinamide hydrochloride(117888-80-9)
• EPA Substance Registry System: (RS)-tyrosinamide hydrochloride(117888-80-9)

Safety Data

• Hazardous Substances Data: 117888-80-9(Hazardous Substances Data)

Upstream product

• 60-18-4 L-tyrosine 
• 3417-91-2 tyrosine methyl ester hydrochloride 
• 556-02-5 ?Tyr 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 3978-80-1 Boc-Tyr-OH 
• 16870-43-2 L-tyrosine hydrochloride 

Downstream Products

• 60-18-4 L-tyrosine 
• 121637-83-0 NPS-Phe-Tyr-NH₂ 
• 74158-38-6 (S)-2-tert-Butoxycarbonylamino-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 100304-69-6 Boc-Tyr-D-Arg(Tos)-Phe-Gly-Tyr-NH₂ 
• 556-02-5 tyrosine 
• 17263-42-2 benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 1593627-69-0 C₂₇H₃₃N₄O₄⁽¹⁺⁾*I^(1-) 
• 1593627-67-8 C₁₇H₂₅ClN₂O₄ 
• 1150315-18-6 creatinyl-tyrosine amide 
• 80621-93-8 sarcosyl-tyrosine amide trifluoracetate 
• 80621-91-6 tert-butyloxycarbonyl-sarcosyl-tyrosine amide 
• 74158-36-4 (S)-2-(2-tert-Butoxycarbonylamino-acryloylamino)-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 74158-42-2 (3S,9S,12S)-6-Hydroxy-9-(4-hydroxy-benzyl)-12-isopropyl-3,6-dimethyl-1-oxa-4,7,10-triaza-cyclododecane-2,5,8,11-tetraone 

Relevant articles and documents

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

Increased Gram-negative bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bacteria that is considered as an interesting drug target. ClpP function is involved in protein turnover and homeostasis, stress response, and virulence among other processes. The focus of this study was to identify new inhibitors of Escherichia coli ClpP and to understand their mode of action. A focused library of serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and a chemical exploration around the hit compounds was conducted. Altogether, 14 new potent inhibitors of E. coli ClpP were identified. Compounds 85 and 92 emerged as most interesting compounds from this study due to their potency and, respectively, to its moderate but consistent antibacterial properties as well as the favorable cytotoxicity profile.

Dichlorotris(dimethylamino)phosphorane as a Dehydratisation Reagent for the Preparation of N-Protected Amino Acid Amides

Besides for the synthesis of peptides and activated esters dichlorotris(dimethylamino)phosphorane (2) now proved to be an excellent reagent for the preparation of N-protected amino acid amides.