117888-80-9

Upstream product

• 16870-43-2 L-tyrosine hydrochloride 
• 60-18-4 L-tyrosine 
• 556-02-5 ?Tyr 
• 3417-91-2 tyrosine methyl ester hydrochloride 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 3978-80-1 Boc-Tyr-OH 

Downstream Products

• 60-18-4 L-tyrosine 
• 121637-83-0 NPS-Phe-Tyr-NH₂ 
• 121637-84-1 Phosphoric acid benzotriazol-1-yl ester 4-{(S)-2-carbamoyl-2-[(S)-2-(2-nitro-phenylsulfanylamino)-3-phenyl-propionylamino]-ethyl}-phenyl ester 2-chloro-phenyl ester 
• 74872-74-5 (S)-2-Amino-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 74872-75-6 (S)-2-(2-Oxo-propionylamino)-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 74158-42-2 (3S,9S,12S)-6-Hydroxy-9-(4-hydroxy-benzyl)-12-isopropyl-3,6-dimethyl-1-oxa-4,7,10-triaza-cyclododecane-2,5,8,11-tetraone 
• 74158-36-4 (S)-2-(2-tert-Butoxycarbonylamino-acryloylamino)-propionic acid (S)-1-[(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethylcarbamoyl]-2-methyl-propyl ester 
• 83351-75-1 tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 1593627-67-8 C₁₇H₂₅ClN₂O₄ 
• 1593627-69-0 C₂₇H₃₃N₄O₄⁽¹⁺⁾*I^(1-) 
• 17263-42-2 benzyl ((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate 
• 556-02-5 tyrosine 
• 1150315-18-6 creatinyl-tyrosine amide 
• 80621-93-8 sarcosyl-tyrosine amide trifluoracetate 

Relevant academic research and scientific papers

α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease

Increased Gram-negative bacteria resistance to antibiotics is becoming a global problem, and new classes of antibiotics with novel mechanisms of action are required. The caseinolytic protease subunit P (ClpP) is a serine protease conserved among bacteria that is considered as an interesting drug target. ClpP function is involved in protein turnover and homeostasis, stress response, and virulence among other processes. The focus of this study was to identify new inhibitors of Escherichia coli ClpP and to understand their mode of action. A focused library of serine protease inhibitors based on diaryl phosphonate warheads was tested for ClpP inhibition, and a chemical exploration around the hit compounds was conducted. Altogether, 14 new potent inhibitors of E. coli ClpP were identified. Compounds 85 and 92 emerged as most interesting compounds from this study due to their potency and, respectively, to its moderate but consistent antibacterial properties as well as the favorable cytotoxicity profile.

Enzymatic synthesis of chiral phenylalanine derivatives by a dynamic kinetic resolution of corresponding amide and nitrile substrates with a multi-enzyme system

Mutant α-amino-ε-caprolactam (ACL) racemase (L19V/L78T) from Achromobacter obae with improved substrate specificity toward phenylalaninamide was obtained by directed evolution. The mutant ACL racemase and thermostable mutant D-amino acid amidase (DaaA) from Ochrobactrum anthropi SV3 co-expressed in Escherichia coli (pACLmut/pDBFB40) were utilized for synthesis of (R)-phenylalanine and non-natural (R)-phenylalanine derivatives (4-OH, 4-F, 3-F, and 2-F-Phe) by dynamic kinetic resolution (DKR). Recombinant E. coli with DaaA and mutant ACL racemase genes catalyzed the synthesis of (R)-phenylalanine with 84% yield and 99% ee from (RS)-phenylalaninamide (400 mM) in 22 h. (R)-Tyrosine and 4-fluoro-(R)-phenylalanine were also efficiently synthesized from the corresponding amide compounds. We also co-expresed two genes encoding mutant ACL racemase and L-amino acid amidase from Brevundimonas diminuta in E. coli and performed the efficient production of various (S)-phenylalanine derivatives. Moreover, 2-aminophenylpropionitrile was converted to (R)-phenylalanine by DKR using a combination of the non-stereoselective nitrile hydratase from recombinamt E. coli and mutant ACL racemase and DaaA from E. coli encoding mutant ACL racemase and DaaA genes. Copyright

Dichlorotris(dimethylamino)phosphorane as a Dehydratisation Reagent for the Preparation of N-Protected Amino Acid Amides

Besides for the synthesis of peptides and activated esters dichlorotris(dimethylamino)phosphorane (2) now proved to be an excellent reagent for the preparation of N-protected amino acid amides.