1178898-08-2Relevant articles and documents
Synthesis and structure-activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity
Shinonaga, Hideki,Noguchi, Toshiya,Ikeda, Akiko,Aoki, Mari,Fujimoto, Natsuko,Kawashima, Akira
experimental part, p. 4622 - 4635 (2009/10/23)
WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for inhibitors of WNT-5A expression. We identified radicicol (1) as an active compound, and synthesized s